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拉米夫定治疗相关HBV变异多发生于活性最强、包含第546－575位氨基酸的C区段酪氨酸－蛋氨酸－天门冬氨酸－天门冬氨酸(YMDD)位点,亦涉及第501－545位氨基酸的B区段。YMDD位点是HBV逆转录酶的活性部分,属高度保守序列。在HBV 的逆转录过程中,
HBV mutation associated with lamivudine treatment mostly occurs in the most active site of tyrosine-methionine-aspartic acid-aspartic acid (C-terminal tyrosine-methionine-aspartic acid-aspartic acid) containing amino acids 546-575, B-segment of amino acids 501-545. YMDD locus is the active part of HBV reverse transcriptase, which is a highly conserved sequence. In the process of HBV reverse transcription,