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目的 探讨酒精性肝病 (ALD)的超微结构特点及其与肝功能损害程度的关系。方法 对 2 0例高原藏族ALD患者行肝穿活检组织病理学观察。结果 酒精性脂肪肝 (AFL)、酒精性肝炎 (AH)、酒精性肝硬化 (ALC)常相继发生或同时存在 ,主要表现为肝细胞大泡性脂变 ,窦周纤维化 ,肝细胞滑面内质网增生 ,小叶内灶状坏死伴中性粒细胞浸润。无论肝超微结构改变轻重 ,均有不同程度的肝功能异常 ,尤其在A/G≤ 1的患者 ,上述改变较重。结论 贮脂细胞的活化状态直接影响到肝病进程及肝功能异常程度。同时讨论了影响酒精性肝损害的其它因素
Objective To investigate the ultrastructural features of alcoholic liver disease (ALD) and its relationship with the degree of liver dysfunction. Methods Histopathological examination of 20 liver biopsy specimens from Tibetan Plateau patients with ALD was performed. Results Alcoholic fatty liver (AFL), alcoholic hepatitis (AH) and alcoholic liver cirrhosis (ALC) often occurred in succession or in combination. The main manifestations were hepatocytic bullous lipidosis, sinus fibrosis, Endoplasmic reticulum hyperplasia, focal lobular necrosis with neutrophil infiltration. Regardless of changes in liver ultrastructure, have varying degrees of liver dysfunction, especially in patients with A / G ≤ 1, the above changes were serious. Conclusion The activated state of the storage fat cells directly affects the course of liver disease and the degree of abnormal liver function. Other factors affecting alcoholic liver damage are also discussed