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载脂蛋白A5是载脂蛋白家族的新成员,它具有较强的表面排斥力和很强的脂质结合能力。在动物与人类研究中发现,它主要参与调节甘油三酯代谢,但两者之间的关系目前研究结果尚不一致。它可通过维持细胞内脂滴的形态、影响肝细胞极低密度脂蛋白-甘油三酯的产生、增加血浆富含甘油三酯脂蛋白的清除及增加脂蛋白脂肪酶和肝酯酶的活性调节甘油三酯的代谢,但其具体机制仍有待进一步研究。
Apolipoprotein A5 is a new member of apolipoprotein family, it has a strong surface repulsion and strong lipid binding capacity. In animal and human studies found that it is mainly involved in the regulation of triglyceride metabolism, but the relationship between the two findings are not the same. It can affect the formation of very low density lipoprotein-triglycerides in hepatocytes, increase the clearance of plasma triglyceride-rich lipoproteins and increase the activity of lipoprotein lipase and hepatic esterase, by maintaining the morphology of intracellular lipid droplets Triglyceride metabolism, but its specific mechanism remains to be further studied.