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与小肠相对无菌状况不同,结肠中存在大量和复杂的菌群(每克内容物约10~(12)).胃肠道实际上是宿主与微生物相互作用的最大区域.从总体上看,胃肠道与正常肠道菌群之间的关系是极其复杂的,尚未被完全认识.动物研究提示肠粘膜正常形成需要接触微生物.正常粘膜免疫系统在保护宿主以及调节与微生物相互作用中的重要性主要通过在正常菌群条件下,特殊的细胞素基因失活的动物中肠病的形成来证实.
In contrast to the relatively sterile condition of the small intestine, there is a large and complex population of colon (about 10-12 per gram of content) .The gastrointestinal tract is actually the largest area where the host interacts with the microorganism Overall, The relationship between the gastrointestinal tract and the normal gut flora is extremely complex and not fully understood Animal studies suggest that the normal formation of the intestinal mucosa requires exposure to microorganisms The importance of the normal mucosal immune system in protecting the host and in regulating interactions with microorganisms Sexuality is mainly confirmed by the formation of enteropathy in animals that are inactivated by special cytokine genes under normal bacterial flora conditions.