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目的分析宁波市育龄期男女弓形虫感染状况及对不孕不育的影响。方法对1 890例育龄期男女用ELISA法检测弓形虫血清抗体,进行流行病学调查,并追踪有无不孕不育史。结果 1 890例宁波地区育龄期男女弓形虫抗体IgG阳性率为6.83%(129/1890),阳性与饲养宠物、爱吃生食物、砧板生熟不分、从事养殖供应肉类职业有关,差异有统计学意义(χ2值分别为106.28、85.67、84.62、7.59,P<0.05)。弓形虫抗体阳性与发生不孕不育间差异有统计学意义(χ2=12.99,P<0.05),与配偶抗体阳性间差异有统计学意义(χ2=5.75,P<0.05)。结论感染弓形虫可能导致不孕不育,育龄期男女加强健康教育及孕前开展弓形虫抗体检测有十分重要的意义。
Objective To analyze the infection status of Toxoplasma gondii in male and female of childbearing age in Ningbo and its influence on infertility. Methods A total of 1890 male and female of reproductive age were tested for serum antibodies to Toxoplasma gondii by ELISA, and the epidemiological investigation was carried out and the history of infertility was followed up. Results The positive rate of IgG antibodies against Toxoplasma gondii in pregnant women and men at 1 890 births in Ningbo was 6.83% (129/1890). The positive rate was in accordance with that of keeping pets and eating raw foods, Statistical significance (χ2 values were 106.28,85.67,84.62,7.59, P <0.05). Toxoplasma gondii antibody positive and infertility occurred between the two groups was statistically significant (χ2 = 12.99, P <0.05), and spouses antibodies positive difference was statistically significant (χ2 = 5.75, P <0.05). Conclusion Toxoplasma gondii infection may lead to infertility. It is very important for men and women of childbearing age to enhance health education and to test the antibody against Toxoplasma gondii before pregnancy.