目的:分析急性重型颅脑损伤患者术后发生持续性昏迷的影响因素，指导未来对急性重型颅脑损伤患者术后持续性昏迷的风险预测及干预。方法:抽取2018年1月至2019年8月在郑州大学第五附属医院接受手术治疗的急性重型颅脑损伤患者92例作为研究对象，观察患者术后持续性昏迷的发生情况。自制一般资料调查表收集患者资料，初步比较发生与未发生持续性昏迷患者的基线资料后行单项Logistic回归分析，然后建立多元回归模型行多因素分析患者术后发生持续性昏迷的影响因素。结果:92例患者中术后发生持续性昏迷33例，发生率为35.87%。发生持续性昏迷患者呼吸异常、低血压、高血糖及脑积水发生率高于未发生持续性昏迷患者(n P1，n P1，n P<0.05)。n 结论:急性重型颅脑损伤患者术后持续性昏迷的发生率高，可能受患者呼吸异常、低血压、高血糖、脑积水等因素影响，临床应重视上述持续昏迷风险因素并及时进行干预，以减少持续性昏迷的发生并改善患者预后结局。“,”Objective:To analyze the influencing factors of persistent coma after surgery for acute severe brain injury, and to guide the corresponding risk prediction and intervention in the future.Methods:Ninety-two patients with acute severe brain injury who received surgery in the Fifth Affiliated Hospital of Zhengzhou University from January 2018 to August 2019 were selected as the research objects. The incidence of postoperative persistent coma was observed. The self-made general information questionnaire was made to collect patients’ data. The baseline data of patients with and without persistent coma were compared and analyzed by single Logistic regression. And then, multiple regression model was established to analyze the influencing factors of postoperative persistent coma.Results:Among the 92 patients, 33 cases had persistent coma, the incidence was 35.87%. The incidences of dyspnea, hypotension, hyperglycemia and hydrocephalus of patients with persistent coma were higher than those of patients without persistent coma (n P1,n P1,n P<0.05).n Conclusions:Patients with acute severe brain injury have a high incidence of persistent coma after surgery, which may be affected by factors, such as abnormal breathing, hypotension, hyperglycemia, and hydrocephalus. The clinicians should pay attention to the risk factors of persistent coma, and give timely intervention, so as to reduce the occurrence of persistent coma and improve the prognosis of patients.