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目的：探讨尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）检测对早期肾损害的诊断价值及临床意义。方法分别对我院340例住院患者和40例健康体检者进行尿NAG、尿微量白蛋白（MALB）、β2-微球蛋白（β2-MG）、α1-微球蛋白（α1-MG）检测。结果340例住院患者中124例患者标本NAG检测结果显著高于健康对照组；87例患者标本β2-MG检测结果显著高于健康对照组；64例患者标本α1-MG检测结果显著高于健康对照组；46例患者标本MALB检测结果显著高于健康对照组。结论尿NAG检测对于早期肾损害的灵敏度优于尿β2-MG、尿α1-MG和尿MALB。对于临床早期发现患者肾损害有一定提示作用，值得临床推广。“,”Objective: To explore diagnostic value of urinary NAG in early renal injury . Methods: 340 cases in our hospital patients and 40 healthy subjects for urinary NAG, urinary albmin(MALB),β2-microglobulin(β2-MG),a1-microglobulin(a1-MG) detection. Results:In 340 cases of hospitalized patients, 120 patients specimens NAG test results were significantly higher than the healthy controls group; 87 patients specimensβ2-MG test results were significantly higher than the healthy controls group; 64 patients specimens a1-MG test results were significantly higher than the healthy controls group; 46 patients specimens MALB test results were significantly higher than the healthy control group. Conclusion: Urinary NAG detection sensitivity for early renal damage than urinary β2-MG, urinary a1-MG and urine MALB. For clinical renal damage in patients with early detection of certain suggestive, worthy of promotion .