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最近我们对美国、加拿大和印度的天然药物研究与开发进行了考察,有以下建议: 1 紫杉醇(Taxol):美国农业部1961年对太平洋紫杉进行采样筛选,1964年证实该植物有抗癌活性,1971年M.E.Wall发表紫杉醇结构及抗癌活性,1977年美国国家癌症研究所(NCI)证实Taxol有独特抗癌机理,1992年美国FDA批准用于治卵巢癌。前后达30年,目前进行的乳腺癌和肺癌临床亦可望成功。据此,可以认为Taxol是近20年来天然抗癌药的重大发现。现在的情况是Bristol-Myers Squibb药厂(BMS)拥有美国专卖权五年(Taxol无专利),已积累Taxol超过100kg,美国每年有12000妇女死于卵巢癌,年需20-25kg(每病人需1.2gm至3gm),
Recently, we reviewed the research and development of natural medicines in the United States, Canada and India and made the following suggestions: 1 Taxol: USDA sampled and screened Pacific yew in 1961 and proved to have anticancer activity in 1964 1971 MEWall published paclitaxel structure and anti-cancer activity, 1977 the United States National Cancer Institute (NCI) confirmed that Taxol has a unique anti-cancer mechanism, the United States FDA approved in 1992 for the treatment of ovarian cancer. Up to 30 years ago, the current clinical trials of breast and lung cancer are also expected to succeed. Accordingly, Taxol can be considered a major discovery of natural anticancer drugs in the past 20 years. The current situation is that Bristol-Myers Squibb Pharmaceuticals (BMS) owns the United States monopoly for five years (Taxol no patent), Taxol has accumulated more than 100kg, the United States each year 12,000 women die of ovarian cancer, annual need 20-25kg (per patient need 1.2 gm to 3 gm),