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目的探讨舒血宁注射液与临床常用输液配伍后的稳定性。方法按照临床用药方法,将舒血宁注射液与5%葡萄糖注射液和0.9%NaCl注射液分别按照高浓度(2∶25)和低浓度(2∶50)进行配伍,考察配伍溶液在室温8h内pH值、不溶性微粒、总黄酮醇苷及银杏内脂A、B、C的含量变化情况。结果舒血宁注射液与5%葡萄糖注射液配伍后8h内pH值未见明显变化,不溶性微粒数符合规定且保持稳定,总黄酮醇苷及银杏内脂A、B、C的含量几乎无变化;与0.9%NaCl注射液配伍后2h后析出少量沉淀。结论舒血宁注射液与0.9%NaCl注射液不宜配伍,与5%葡萄糖注射液配伍8h内基本稳定。
Objective To investigate the stability of Shuxuening injection combined with common clinical infusion. Methods According to the clinical application method, Shuxuening injection and 5% glucose injection and 0.9% NaCl injection were respectively matched with high concentration (2:25) and low concentration (2:50), and the compatibility of the solution at 8h PH value, insoluble particles, total flavonol glycosides and ginkgolides A, B, C content changes. Results Shuxuening injection and 5% glucose injection within 8h compatibility did not change significantly, the number of insoluble particles in line with the provisions and remained stable, total flavonol glycosides and ginkgolides A, B, C content almost no change ; 2 hours after mixing with 0.9% NaCl injection, a small amount of precipitate precipitated. Conclusion Shuxuening injection and 0.9% NaCl injection should not be compatible with 5% glucose injection compatibility within 8h basically stable.