目的报告继发急性髓细胞白血病(M4EO型)的慢性斑块状银屑病1例临床研究及骨髓移植治疗。方法采用临床资料收集,组织病理检查,骨髓和外周血涂片检查,利用流式细胞仪进行细胞免疫分型,用骨髓细胞体外培养做染色体检查及G显带分析。结果患者女,33岁,有寻常性银屑病史20余年,反复出现红斑鳞屑,皮损以斑块为主,有家族史,用多种方法治疗(以中药为主)。近来不明原因肌肉酸痛,牙龈出血,发热伴胸骨叩痛。骨髓检查发现异常幼稚单核细胞及早幼粒细胞,并见含有粗大嗜碱颗粒的嗜酸粒细胞,确诊为急性髓细胞白血病M4EO型,经骨髓细胞免疫分型检查符合诊断。骨髓细胞体外培养做染色体检查,+G-显带发现inv(16)的克隆异常和+8克隆异常,染色体核型为46,XX,inv(16)/47,XX,inv(16),+8(2/22)。经异基因骨髓移植治疗,银屑病皮损完全消退,急性髓性白血病症状缓解,骨髓异常幼稚细胞减少,病情得到有效控制。结论为国内首例寻常性银屑病(斑块状)继发急性髓细胞白血病M4EO型的临床研究及骨髓移植治疗 Objective To report a case of chronic plaque psoriasis secondary to acute myeloid leukemia (M4EO type) and one case of bone marrow transplantation. Methods Clinical data collection, histopathological examination, bone marrow and peripheral blood smears were performed. Cell immunophenotyping was performed by flow cytometry. Chromosome examination and G-banding analysis were performed with bone marrow cells cultured in vitro. Results The female patient, 33 years old, had a history of psoriasis vulgaris for more than 20 years. Repeated erythema and squamous cell carcinomas were mainly plaques and had a family history. They were treated with various methods (mainly traditional Chinese medicine). Recent unexplained muscle soreness, bleeding gums, fever with sternal chest pain. Bone marrow examination found abnormal naive monocytes and promyelocytic cells, and see with coarse basophilic granules of eosinophils, diagnosed as acute myeloid leukemia M4EO type, the bone marrow cell immunophenotypic examination consistent with the diagnosis. The myeloid cells were cultured in vitro for chromosomal examination, and the inv (16) / 47, XX, inv (16), + 8 (2/22). The allogeneic bone marrow transplantation, psoriasis lesions completely subsided, acute myeloid leukemia symptoms alleviated, bone marrow abnormal naive cells decreased, the disease was effectively controlled. Conclusions for the first case of psoriasis vulgaris (plaque-like) secondary to acute myeloid leukemia M4EO clinical studies and bone marrow transplantation