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人类和动物研究均表明回肠切除增加了胆石形成的危险,但原因仍然不清。本研究试图确定回肠切除诱发结石,究竟是由于胆红素还是胆固醇代谢改变所引起。本研究选用犬鼠为实验动物,分别经下腹正中切口施行回肠切除术(IR)和单纯开腹术(SL)。实验Ⅰ24例,回肠切除、小肠盲肠端侧吻合16例(切除范围为小肠总长的45%)。开腹术8例。所有动物术前均用标准低胆固醇饮食喂养1周,术后第2天供给饮水,第3天起喂养标准饮食4周。实验Ⅱ为确定
Both human and animal studies suggest that ileal resection increases the risk of gallstone formation, but the reason remains unclear. This study sought to determine if ileal-induced calculus is caused by altered bilirubin or cholesterol metabolism. In this study, canine and rat were selected as experimental animals, and the ileum resection (IR) and simple open surgery (SL) were performed through the incision of the midline of the lower abdomen respectively. Experiment Ⅰ24 cases, ileal resection, end-to-end anastomosis of the small intestine in 16 cases (resection range of 45% of the total length of the small intestine). Open surgery in 8 cases. All animals were fed a standard low-cholesterol diet for one week before surgery, drinking water on the second day after surgery, and a standard diet on the third day for four weeks. Experiment Ⅱ to determine