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检测了31例缺氧缺血性脑病（HIE）新生儿日龄＜3日（Ⅰ）次及7日（Ⅱ）次及30例尺月正常新生儿血浆中β－内啡肽（β－EP）。结果表用，HIE患儿血浆中β－EP不论Ⅰ或Ⅱ次均明显高于对照组，P＜0．05及0．01，提示HIE时β－EP参与并加重了该病的发生。此外惊厥组15例均比无惊厥组16例及正常组明显增高P各为＜0．01及＜0．05。提示β－EP可能对导致HIE惊厥有一定的影响。文章指出对重度患儿及早采用纳洛酮及β－EP抗血清治疗可以预防及减轻HIE的脑损伤。
A total of 31 neonates with hypoxic-ischemic encephalopathy (HIE) were enrolled in the study. The plasma β-EP (β-EP ). Results table, β-EP in plasma of children with HIE was significantly higher than that of the control group Ⅰ or Ⅱ, P <0.05 and 0.01, suggesting that β-EP is involved in HIE and aggravates the occurrence of the disease. In addition, 15 cases of convulsion group than those without convulsion group and 16 cases of normal group were significantly higher P <0.01 and <0.05 respectively. Tip β-EP may lead to HIE seizures have a certain impact. The article points out that the early treatment of severe children with naloxone and β-EP antiserum can prevent and reduce brain injury in HIE.