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目的:通过与肝刺激因子(HSS)保肝作用的比较,评估益气软肝方(PGSL)对肝纤维化的保护作用。方法:大鼠肝纤维化模型由人血清白蛋白制备,PGSL保护组予PGSL中药汤剂每日两次灌胃,HSS保护组同时予HSS每周两次腹腔内注射,共8周。结果:PGSL及HSS均可以降低肝纤维化大鼠的死亡率;肝组织羟脯氨酸测定、大体标本、HE染色、嗜银及VG染色,提示二者均可以降低大鼠肝纤维化的增生程度。上述两个保护组比较均无统计学差异。结论:益气软肝方预防肝纤维化的作用与肝刺激因子相似。
OBJECTIVE: To evaluate the protective effect of Yiqi Ruangan Decoction (PGSL) on liver fibrosis by comparing with the hepatoprotective effect of hepatic stimulating factor (HSS). Methods: The model of rat liver fibrosis was prepared by human serum albumin. The PGSL protection group was treated with PGSL Chinese herbal decoction twice a day. The HSS protection group was given HSS twice a week by intraperitoneal injection for 8 weeks. Results: Both PGSL and HSS could reduce the mortality of hepatic fibrosis rats. The hydroxyproline in liver tissue, gross specimen, HE staining, argyrophil and VG staining suggested that both of them could reduce the proliferation of hepatic fibrosis in rats degree. There was no significant difference between the two protection groups. Conclusion: The effect of Yiqi Ruangan Decoction in preventing liver fibrosis is similar to that of hepatic stimulating factor.