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目的:探讨糖皮质激素对急性中耳炎(AOM)中耳积液的疗效。方法:以43例(43耳)有明显鼓室压图异常的AOM患者为对象,采用前瞻性随机对照研究,对其中的23例(23耳)使用地塞米松加头孢呋辛钠进行治疗(试验组),另外20例(20耳)仅使用头孢呋辛钠进行治疗(对照组),随访治疗后鼓室压图的变化。结果:对照组鼓室压图恢复正常的时间为(54.6±6.2)d,试验组的时间为(38.5±6.1)d,经t检验2组间差异有统计学意义(P<0.05);在治疗后3个月,试验组的鼓室压图恢复率高于对照组。结论:糖皮质激素对AOM急性期中耳积液有明显的改善作用,可明显缩短中耳积液的时间,且对长程或慢性的中耳积液有一定的改善作用,是一种有效的辅助治疗方法。
Objective: To investigate the effect of glucocorticoids on middle ear effusion of acute otitis media (AOM). Methods: A total of 43 patients (43 ears) with AOM in patients with significant tympanographic abnormalities were enrolled in this study. Twenty-three patients (23 ears) were treated with dexamethasone and cefuroxime axetil in a prospective randomized controlled trial Group), while the other 20 cases (20 ears) were treated with cefuroxime sodium alone (control group). The change of tympanogram was followed up. Results: In the control group, the tympanogram returned to normal in 54.6 ± 6.2 days, and the time in the test group was (38.5 ± 6.1) days. There was significant difference between the two groups by t test (P <0.05) Three months later, the tympanogram recovery rate of the experimental group was higher than that of the control group. Conclusion: Glucocorticoids can significantly improve the effusion of middle ear in acute stage of AOM, shorten the time of middle ear fluid effusion and improve the long-term or chronic middle ear effusion, which is an effective adjuvant treatment method.