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腺相关病毒(AAV)能感染非分裂期的细胞,对宿主几无致病性及能使宿主长期稳定的表达外源基因,是神经系统疾病基因治疗的常用载体。不同血清型的AAV,由于分子结构与细胞结合机制的差异,在组织细胞中常表现出不同的转导效率。为了寻求更有效的中枢神经系统疾病基因治疗的方法,有必要对各型AAV在神经系统组织细胞内的转导特性进行深入的研究。
Adeno-associated virus (AAV) can infect non-dividing cells, have few pathogenicity to the host and can make the host long-term and stable expression of foreign genes, which is a common vector for gene therapy of nervous system diseases. Different serotypes of AAV, due to differences in the molecular structure and cell binding mechanisms, often show different transduction efficiency in the tissue cells. In order to find a more effective method of gene therapy for CNS diseases, it is necessary to conduct an in-depth study on the transduction characteristics of various types of AAV in neuronal tissue cells.