目的　探讨肿瘤坏死因子α(TNF α)在早期流产中的作用。方法　采用ELISA双抗体夹心法测定 35例早期流产患者血清TNF α浓度。结果　早期流产患者血清TNF α显著高于正常非孕妇女及正常怀孕妇女 ,而且难免流产组明显高于先兆流产组。结论　提示血清TNF -α浓度升高可作为早期流产的活动性预测指标 Objective To investigate the role of tumor necrosis factor α (TNF α) in early abortion. Methods Serum TNFα levels in 35 cases of early abortion were measured by ELISA double antibody sandwich method. Results The serum level of TNFα in early abortion patients was significantly higher than that in normal non-pregnant women and normal pregnant women, and it was inevitable that abortion group was significantly higher than threatened abortion group. Conclusions suggest that elevated serum TNF-α levels can be used as early predictors of abortion activity