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作者报道一例慢性丙型肝炎患者对干扰素和利巴韦林治疗无反应,而在肺结核复发后肝炎获得痊愈。 患者女性、27岁,实验室技术员。1989年曾因肺结核应用抗痨药物治疗1年。1995年7月被针头刺伤后发生急性丙型肝炎,因患者的血清转氨酶水平持续升高,同年12月行肝活检进一步确诊,并应用干扰素(3MU,每周3次)治疗6个月。但此后血清HCVRNA仍为阳性,ALT波动在64～203U/L。1998年2月第二次肝活检示慢性丙型肝炎(Knodell指数为5,纤维化评分为1),病毒基因分型为1b,病毒负荷为300 000拷贝/
The authors report that one patient with chronic hepatitis C did not respond to interferon and ribavirin therapy and healed after tuberculosis relapsed. Patient female, 27 years old, lab technician. In 1989, tuberculosis was treated with anti-tuberculosis drugs for 1 year. Hepatitis C was acutely stabbed in July 1995 after the needles were stabbed. The patient’s serum aminotransferase level continued to rise. In December of the same year, he was further confirmed by liver biopsy and treated with interferon (3MU 3 times a week) for 6 months . However, serum HCVRNA was still positive after that, and ALT fluctuated between 64 and 203 U / L. The second liver biopsy in February 1998 showed chronic hepatitis C (Knodell index of 5, fibrosis score of 1), genotyping of the virus to 1b, viral load of 300 000 copies /