本文采用放射免疫法测定了 1 32例糖尿病患者的血、尿内皮素水平 ,其中有糖尿病肾病 (DN) 53例。结果表明 :糖尿病患者血、尿内皮素水平较正常对照组升高明显 ,P <0 0 5;而DN患者较正常对照组比较升高更明显 ,P <0 0 1。由上可看出 :血、尿内皮素水平的升高 ,与糖尿病血管病变有关 ,可作为糖尿病血管病变的证据之一 In this paper, radioimmunoassay was used to determine the levels of blood and urine endothelin in 112 cases of diabetic patients, including 53 cases of diabetic nephropathy (DN). The results showed that blood and urinary endothelin levels in diabetic patients increased significantly compared with those in normal controls (P <0.05), while those in DN patients increased more significantly than those in normal controls (P <0.01). It can be seen from the above: blood, increased levels of urinary endothelin, and diabetic vascular disease can be used as evidence of diabetic vascular disease