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目的观察灯盏细辛注射液加用纳洛酮治疗急性脑梗死患者的临床疗效。方法80例急性脑梗死患者发病72 h 内的急性期病例随机分为治疗组和对照组两组,两组均予降颅压、控制血压、抗生素控制感染、维持水电解质酸碱平衡及对症支持治疗,对照组另用灯盏细辛注射液静脉滴注,治疗组用灯盏细辛注射液加用纳洛酮静脉滴注,均每日1次,连用2周。观察两组治疗前后的临床疗效、神经功能缺损评分。结果治疗组总有效率为92.5%,对照组为77.5%,两组疗效对比、神经功能缺损评分改善治疗组均明显优于对照组,有统计学意义(P<0.01)。均未发现有明显不良反应。结论灯盏细辛注射液和纳洛酮的联合使用可改善脑梗死神经功能缺损,提高疗效,降低致残率。
Objective To observe the clinical efficacy of Dengzhanxixin injection plus naloxone in patients with acute cerebral infarction. Methods Eighty patients with acute cerebral infarction within 72 hours after onset were randomly divided into treatment group and control group. Both groups were given intracranial pressure, blood pressure control, antibiotics to control infection, maintain the acid-base balance of water and electrolyte and symptomatic support Treatment, the control group with other Erigeron Injection intravenous drip, the treatment group with Erigeronis Injection plus naloxone intravenous infusion, once daily for 2 weeks. The clinical efficacy and neurological deficit scores of two groups before and after treatment were observed. Results The total effective rate was 92.5% in the treatment group and 77.5% in the control group. There was significant difference between the two groups in curative effect and improvement of neurological deficit score in the treatment group (P <0.01). No significant adverse reactions were found. Conclusion The combination of Erigeron Breviscapus Injection and naloxone can improve neurological deficit of cerebral infarction, improve curative effect and reduce morbidity.