论文部分内容阅读
目的：观察托吡酯（商品名妥泰，ＴＰＭ）治疗部分性癫 发作的临床疗效和安全性。方法：应用 ＴＰＭ对１０３例部分性癫 发作患者进行开放性自身对照治疗试验。根据病人临床上对ＴＰＭ的客观反应，调整其剂量和合并用药。结果：ＴＰＭ对于部分性发作的总有效率为６１．６％（其中简单部分性发作为 ５４．８％，复杂部分性发作为 ６７．１％，继发全身性发作为６０％），发作完全控制为 ７．８％，各型癫 发作形式的疗效之间无显著性差异；其不良反应大多发生在用药后一个月内，以体重下降最明显。结论：ＴＰＭ是一种广谱、有效、安全的新型抗癫 药物，对于部分性发作均明显有效，不良反应轻，值得推广应用。
Objective: To observe the clinical efficacy and safety of topiramate (TPT) in the treatment of partial epilepsy. Methods: A total of 103 patients with partial epilepsy were enrolled in the open-label self-controlled trial. According to the patient’s objective clinical response to TPM, adjust the dose and the combination of medication. RESULTS: The overall effective rate of TPM for partial seizures was 61.6% (54.8% in simple partial seizures, 67.1% in complex partial seizures and 60% in secondary generalized seizures), and seizures were complete Control of 7.8%, the type of epileptic seizures no significant difference between the efficacy; most of its adverse reactions occurred within one month after treatment, the most obvious weight loss. Conclusion: TPM is a broad spectrum, effective and safe new antiepileptic drugs. It is effective in partial seizures and has mild adverse reactions. It is worth popularizing and applying.