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抗核抗体(ANA)最初通过红斑狼疮(LE)细胞现象而发现.LE细胞的形成基本上是一种实验现象,在循环血中很少发现.LE细胞试验现已不常采用,但仍具有对系统性红斑狼疮细胞特异性较高之优点.1957年,Holborow首先采用了ANA免疫荧光试验,该法灵敏度高,特异性较低,但使用范围很广,可检测多种抗核抗体.此外,尚可观察到多种染色型,后者在某种程度上与不同部位的结缔组织病有着相应联系.新近已从分子水平上对抗核抗体进行了研究,并将有关认识运用于相关疾病.
Antinuclear antibodies (ANA) were originally found by the phenomenon of lupus erythematosus (LE) cells. The formation of the LE cells is essentially an experimental phenomenon that is rarely found in circulating blood. ELE cell assays are infrequently used but still have In 1957, Holborow first used ANA immunofluorescence assay, the method of high sensitivity, low specificity, but the use of a wide range, can detect a variety of anti-nuclear antibodies.In addition , A variety of stained types can be observed, the latter is to some extent associated with connective tissue disease in different parts of the body has recently been on the molecular level of anti-nuclear antibodies were studied and applied to related diseases awareness.