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用125I标记示踪法研究大鼠皮下注射聚乙二醇化重组人生长激素(PEG-rhGH)药代动力学特征。大鼠scPEG-rhGH后,测定血清PEG-rhGH浓度,用3P97程序拟和分析并计算药代动力学参数。大鼠scPEG-rhGH150、300或600μg.kg-1后,药物消除符合一房室模型。经与相关文献比较可知,生长激素经PEG化修饰后能延长其在体内的作用时间,达到长效目的。
The pharmacokinetics of PEG-rhGH was subcutaneously injected into rats by 125I labeling. After scPEG-rhGH, the concentration of serum PEG-rhGH was measured. The pharmacokinetic parameters were calculated by 3P97 program. After scPEG-rhGH 150, 300 or 600 μg.kg-1, the drug disappeared in a one-compartment model. Compared with the relevant literature shows that growth hormone PEGylated modification can extend its role in the body time to achieve long-term purpose.