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已有报道,高龄大鼠骨矿物质丢失直接或间接由于骨吸收增加,并认为这种骨矿物质丢失能够被适当剂量的异丙嗉预防或逆转。本研究在于观察异丙嗪能否阻断和逆转已有明显椎骨矿物质减少的绝经后妇女的骨丢失。对象与方法绝经后妇女脊椎(L_2～L_4)骨矿物质含量低于正常2个标准差者86例,随机分为两组。A组:41例,给予碳酸钙500mg、每日二次,其中26例完成24个月实验观察,26例中同时服用雌激素者10例。B组:45例,给予碳酸钙500mg、每日二次,同时给予异丙嗪25mg、每日二次口服,其中28例完成24个月实验观察,28例中同时服用雌激素者8例。二组之间年龄、身高、体重、民族、绝经后年限等均相匹配。所有受试者每6个月检查一
It has been reported that bone mineral loss in older rats increases either directly or indirectly due to bone resorption and that such bone mineral loss can be prevented or reversed by the appropriate dose of isopropyl. The aim of this study was to investigate whether promethazine blocks and reverses bone loss in postmenopausal women who already have significant reductions in vertebral mineral mass. Subjects and Methods 86 postmenopausal women with spinal cord (L_2 ~ L_4) bone mineral content less than 2 standard deviations were randomly divided into two groups. In group A, 41 cases were given 500 mg of calcium carbonate twice a day, of which 26 cases completed 24 months experimental observation and 26 cases took estrogen at the same time in 10 cases. In group B, 45 cases were given calcium carbonate 500 mg twice daily while promethazine was given 25 mg twice daily orally. Among them, 28 cases completed 24 months experimental observation and 28 cases took estrogen simultaneously. Two groups of age, height, weight, ethnicity, age and other post-menopause match. All subjects checked every 6 months