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目的总结临床中抗结核药物导致肝损害的临床表现及诊治情况。方法选取我院2011年2月至2016年2月58例抗结核药物所致肝损害患者作为研究对象,对58例患者的临床表现及用药前后的肝功能改变情况进行分析。结果本组58例结核患者,应用抗结核药物治疗后所致肝脏轻度损害30例,中度损害16例,重度损害12例;经调整药物剂量和加强保肝治疗1个月后肝功恢复正常。结论在进行抗结核药物治疗时,应充分了解患者的病情、病史等,选择对患者危害性较小的抗结核药物,并采取适当的护肝措施,以尽可能减少药物性肝损害的发生,保证抗结核治疗的顺利进行。
Objective To summarize the clinical manifestation, diagnosis and treatment of liver damage caused by anti-tuberculosis drugs in clinic. Methods From February 2011 to February 2016, 58 patients with liver damage caused by anti-TB drugs were selected as the research object. The clinical manifestations and changes of liver function in 58 patients before and after treatment were analyzed. Results The group of 58 patients with tuberculosis, anti-TB drug treatment caused mild liver damage in 30 cases, 16 cases of moderate damage, severe damage in 12 cases; adjusted drug dose and enhance liver protection 1 month after liver function recovery normal. Conclusion In the anti-TB drug treatment, we should fully understand the patient’s condition, history, etc., choose less harmful to patients with anti-TB drugs, and take appropriate hepatoprotective measures to minimize the occurrence of drug-induced liver damage, Ensure the smooth progress of anti-TB treatment.