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目的 :研究原发性中耳癌人类乳头状瘤病毒 (H PV) DNA的表达情况。方法 :采用多聚酶链反应技术 ,对 5例中耳癌的病理组织蜡块进行 HPV - DNA类型的检测 ,以 8例慢性化脓性中耳炎中耳乳突粘膜为对照组。结果 :5例中耳癌高危型 HPV感染率为 80 % (4 /5 ) ,以 HPV1 6型感染为主 ,而对照组 HPV感染率为 0 % (0 /8) ,经 χ2检验 ,P <0 .0 1。结论 :中耳癌高危型 HPV感染率较高 ,慢性化脓性中耳炎和中耳胆脂瘤以及 HPV感染可能在中耳癌的发生发展中起着重要作用
Objective: To study the expression of H PV DNA in primary middle ear cancers. Methods: Polymerase chain reaction (PCR) was used to detect the HPV - DNA type in 5 cases of middle ear cancer tissues. 8 cases of chronic suppurative otitis media were treated as control group. Results: The prevalence of high-risk HPV infection in 5 cases of middle ear cancer was 80% (4/5), with HPV1 6 infection as the control group and 0% (0/8) in the control group. By χ2 test, P < 0 .0 1. CONCLUSIONS: High-risk HPV infection is high in middle ear cancers and chronic suppurative otitis media and middle ear cholesteatoma and HPV infections may play an important role in the development of middle ear cancers