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目的:探讨长托宁和阿托品作为小儿全凭静脉麻醉术前用药的效果。方法:将80例在我院门诊行腹部简单手术的小儿患者随机均分为两组,分别于入室后静脉给予长托宁0.012mg/kg(A组)或阿托品0.012mg/kg(B组),观察注药后10、20、30min的血压、心率、脉氧饱和度、口干程度、及镇静程度。结果:B组心率与基础值比较明显加快,A组心率无明显变化(P﹥0.05),镇静作用优于B组(P﹤0.05)。结论:长托宁具有很好的抑制腺体分泌作用、维持心血管功能稳定和良好的中枢镇静作用,能有效预防术中知晓,是小儿理想的术前用药。
Objective: To investigate the effect of penehyclidine and atropine as premedication for pediatric total intravenous anesthesia. Methods: A total of 80 pediatric patients undergoing simple abdominal operation in our hospital were randomly divided into two groups. After long-term intravenous administration of long-acting 0.012 mg / kg (group A) or atropine 0.012 mg / kg (group B) The blood pressure, heart rate, pulse oxygen saturation, dry mouth and sedation were observed at 10, 20 and 30 minutes after injection. Results: Compared with group B, the heart rate of group B was significantly faster than that of group B (P <0.05). The sedation rate of group A was superior to that of group B (P <0.05). CONCLUSION: Penehyclidine has a good inhibitory effect on glandular secretion, maintains stable cardiovascular function and good central sedation, and can effectively prevent intraoperative awareness. It is an ideal preoperative medication for infants.