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目的：评价不同通气方式的通气效果并探讨通气作用原理．方法：通过蒸汽吸入致伤，复制了９只犬Ⅱ型呼吸衰竭模型．结果：①当限定ＣＭＶ峰值气道压≤１２ｃｍＨ２Ｏ时，有ＣＯ２潴留，不能满足通气要求；②ＨＦＪＶ＋ＰＥＥＰ与单纯ＨＦＪＶ相比较，Ｖｃｏ２（２．９１±１．０９对４．９０±０．６５ｍｌ／（ｍｉｎ·ｋｇ）显著减少（Ｐ＜０．０１），Ｐａｃｏ２（１０．２８±１．３６对７．０５±１．３７ｋＰａ）大幅度增加（Ｐ＜０．０１），Ｐａｏ２（７．２３±２．２７对９．３３±２．１８ｋＰａ）显著降低（Ｐ＜０．０１），可能与ＶＴ和ＶＡ的减少有关；③ＨＦＴＪＶ与ＨＦＪＶ相比较，Ｖｃｏ２（６．３２±１．３０ｍｌ／（ｍｉｎ·ｋｇ）增加，Ｐａｃｏ２（５．９９±０．９０ｋＰａ）减少均达到非常显著水平（Ｐ＜０．０１），Ｐａｏ２维持稳定．结论：ＨＦＴＪＶ确有增强ＣＯ２的排除效能，其作用应归因于解剖和生理死腔量的减少，其可能成为解决Ⅱ型呼吸衰竭ＣＯ２排除障碍的有效途径．
Objective: To evaluate the ventilation effect of different ventilation modes and to explore the principle of ventilation. METHODS: Nine dogs with type II respiratory failure were reproduced by steam inhalation injury. Results: ①When the peak airway pressure of CMV was limited to ≤12cmH2O, there was CO2 retention, which could not meet the ventilation requirements. ② Compared with HFJV alone, Vco2 (2.91 ± 1.09 vs. 4.90 ± 0.65ml / (min · Kg (P <0.01), Paco2 (10.28 ± 1.36 vs 7.05 ± 1.37kPa) increased significantly (P <0.01) and Pao2 (7.23 ± 2. 27 vs 9.33 ± 2.18 kPa) (P <0.01), which may be related to the reduction of VT and VA. ③ Compared with HFJV, VFT2 (6.32 ± 1.30ml / (min · kg) (5.99 ± 0.90kPa), and Pao2 remained stable.Conclusion: HFTJV does enhance the CO2 removal efficiency, and its role should be attributed to the anatomy and physiology Dead space Reduction, it may be an effective way to solve the CO2 type Ⅱ respiratory failure exclude disorders.