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硝苯吡啶是一种临床用途广泛的钙离子拮抗剂,其对血流动力学的影响主要表现为心率增加、心输出量增加、外周阻力下降、外周血流增加、动脉压下降和心室内压下降等。硝苯吡啶吸收快,血浆半衰期为4h,80％从尿排出。其临床适应症是心绞痛、高血压和左心衰竭,效果肯定。常见副作用有眩晕、体液潴留、上消化道症状、头痛、灼热、无力等,但发生率低,大多能自动消失,相当安全。
Nifedipine is a clinically useful calcium antagonist, its hemodynamic effects are mainly manifested as increased heart rate, increased cardiac output, decreased peripheral resistance, increased peripheral blood flow, decreased arterial pressure and ventricular pressure Drop and so on. Nifedipine absorption fast plasma half-life of 4h, 80% from the urine. Its clinical indications are angina, hypertension and left heart failure, the effect is certain. Common side effects are dizziness, fluid retention, upper gastrointestinal symptoms, headache, burning, weakness, etc., but the incidence is low, most can disappear automatically, quite safe.