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异烟肼(INH)应用于临床已有20余年,由于疗效较高,价格低廉,使用方便,口服后吸收迅速,能比较均匀地分布于全身各组织包括脑脊液中,因而直至目前仍为治疗结核病的首选药物。遵照毛主席关于“我们必须学会全面地看问题,不但要看到事物的正面,也要看到它的反面”的教导,我们还必须看到INH可能引起的副作用,采取相应防治措施,使这种药物在临床上得到更合理的应用。 INH副作用的发生机理发生率与剂量有关。当本品剂量在5毫克/公斤/日以内时,副作用发生率极低,如剂量超过10毫克/公斤/日,则副作用的发生率可高达15％以上。
Isoniazid (INH) has been used clinically for more than 20 years and has been used to treat tuberculosis until now due to its high efficacy, low cost, ease of use, rapid absorption after oral administration, and relatively uniform distribution throughout the body including cerebrospinal fluid The preferred drug. In accordance with Chairman Mao’s teachings that “we must learn to look at the issue in a comprehensive way, we must not only see the positive aspects of things, but also see the opposite aspects of them.” We must also see the possible side effects caused by INH and take appropriate preventive measures to make this Drugs in the clinical get more reasonable application. The incidence of INH side effects and dose-related mechanism. When the dose of 5 mg / kg / day or less, the incidence of side effects is extremely low, such as the dose exceeds 10 mg / kg / day, the incidence of side effects can be as high as 15%.