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目的分析非高密度脂蛋白胆固醇(Non-HDL-C)与急性冠脉综合征(ACS)患者早期再发主要心血管事件(MACE)的关系,探讨Non-HDL-C对ACS患者早期再发MACE的预测价值。方法采用病例对照研究方法,收集408例ACS患者入院时临床资料,通过院内观察和院外随访记录发病30 d内再发MACE的情况,根据是否再发MACE将患者分为事件组和非事件组,比较分析两组间各指标的差异。结果 1事件组的基线Non-HDL-C水平明显高于非事件组〔(3.6±0.7)mmol/L vs.(3.2±0.6)mmol/L,P<0.01〕。2多因素logistic回归分析显示NonHDL-C、超敏C反应蛋白(hs-CRP)、红细胞分布宽度(RDW)、年龄是再发MACE的危险因素,高密度脂蛋白胆固醇(HDL-C)则是显著的保护因素。3受试者工作特征曲线(ROC曲线)显示Non-HDL-C的曲线下面积为0.672(95%CI:0.610-0.735),当截断点选定3.31 mmol/L时,其预测效率最高,灵敏度为68.3%,特异度为64.3%。结论 Non-HDL-C是ACS患者早期再发MACE的危险因素,对ACS患者早期再发MACE有一定预测价值。
Objective To analyze the relationship between non-HDL-C and major cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) and to explore the role of Non-HDL-C in the early recurrence of ACS MACE predictive value. Methods A case-control study was conducted to collect the clinical data of 408 patients with ACS admitted to hospital. The patients underwent MACE within 30 days after hospitalization and hospital follow-up. The patients were divided into incident group and non-incident group according to MACE. Comparative analysis of the differences between the two indicators. Results The baseline Non-HDL-C level in group 1 was significantly higher than that in non-group [(3.6 ± 0.7) mmol / L vs. (3.2 ± 0.6) mmol / L, P <0.01). (2) Multivariate logistic regression analysis showed that Non-HDL-C, hs-CRP, RDW and age were the risk factors of recurrent MACE. High-density lipoprotein cholesterol (HDL-C) Significant protective factors. 3 The receiver operating characteristic curve (ROC curve) showed that the area under the curve of Non-HDL-C was 0.672 (95% CI: 0.610-0.735). When the cutoff point was 3.31 mmol / L, the prediction efficiency was the highest. 68.3%, specificity was 64.3%. Conclusion Non-HDL-C is a risk factor for early recurrence of MACE in patients with ACS, and has some predictive value for the early recurrence of MACE in patients with ACS.