Blue economic zone is a typical regional economic mode, which is specially characterized by marine economy and has multiple economic types coexisting and interacting through integrating marine and land resources. With the continuous progress of science and technology, marine economy as a strategy to promote economic development is approved in many countries. The Blue Shandong Peninsula Economic Zone (BSPEZ) reflects the local demands of economic development, and its upgrading and enhancing competitiveness of the industrial structure is also of obvious significance for enhancement of the development of eastern China and the national marine economy. This paper thinks that the BSPEZ has many advantages, such as unique marine economy, growing high-tech industries, more and more mature industrial system, advancing technological innovation, and outstanding big enterprises, large projects and regional bright brands, but it is also facing problems of low industry cluster, similar industrial structure with each other, still weak technological innovation. So we put forwards the basic approaches to upgrade and enhance the industrial structure: transforming and upgrading the traditional marine industries with advantages, accelerating the development of new marine industries and high-tech industries, integrating marine and land industry, and promoting the rational system arrangements.