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目的探讨年轻(≤35岁)宫颈癌患者临床、病理及预后特点。方法回顾性分析2005年1月-2008年9月我院≤35岁65例宫颈癌患者的临床、病理及随访资料。结果≤35岁宫颈癌患者占同期住院治疗的宫颈癌患者的17.0%(65/382)。年轻宫颈癌患者以低分化鳞癌为多见,非鳞癌患者淋巴结转移率高于鳞癌患者(P=0.000)。FIGO早期患者鳞癌的5年生存率较非鳞癌为高,差异有统计学意义(P=0.001)。FIGO晚期患者中,鳞癌的5年生存率与非鳞癌类似,差异无统计学意义(P=0.176)。存在高危病理因素患者5年生存率较无高危病理因素患者为低(P<0.05)。结论伴有高危病理因素的年轻宫颈癌患者应加强随访,给予积极的辅助治疗,以期提高生存率。
Objective To investigate the clinical, pathological and prognostic features of young (≤35 years) cervical cancer patients. Methods The clinical, pathological and follow-up data of 65 patients with cervical cancer ≤35 years old in our hospital from January 2005 to September 2008 were retrospectively analyzed. Results Cervical cancer patients ≤ 35 years old accounted for 17.0% (65/382) of cervical cancer patients hospitalized in the same period. In young patients with cervical cancer, poorly differentiated squamous cell carcinoma is more common. The rate of lymph node metastasis in non-squamous cell carcinoma patients is higher than that in squamous cell carcinoma patients (P = 0.000). FIGO patients with early 5-year survival rate of squamous cell carcinoma than non-squamous cell carcinoma was higher, the difference was statistically significant (P = 0.001). In the patients with advanced FIGO, the 5-year survival rate of squamous cell carcinoma was similar to that of non-squamous cell carcinoma, with no significant difference (P = 0.176). The 5-year survival rate of patients with high-risk pathologic factors was lower than that without high-risk pathological factors (P <0.05). Conclusions Young cervical cancer patients with high-risk pathological factors should be followed up and given active adjuvant therapy in order to improve the survival rate.