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  5. Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones

Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：cqwsly
【摘 要】
：
Sixteen novel 6-and 2-(1-aeylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their eytotoxicifies were evaluated in vitro against
【作 者】
：
Li Ming Zhao Tian Pei Xie Yu Q 
【机 构】
：
School of Pharmacy,Shanghai Standard Biotech Co.Ltd.
【出 处】
：
中国化学快报（英文版）
【发表日期】
：
2004年期
【关键词】
：
5 8-Dimethoxy-1 4-naphthoquinone derivatives Synthesis Antimmor activity 
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论文部分内容阅读
Sixteen novel 6-and 2-(1-aeylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their eytotoxicifies were evaluated in vitro against BEL-7402,HT-29 and SPC-Al cell lines.The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line.Compound 16b exhibited the most potent antitumor activity among the tested compounds.
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