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侧群(side population,SP)细胞是一小群能够将染料Hoechst 33342排出从而在流式细胞图上呈现Hoechst 33342低染的细胞,研究者已在多种肿瘤组织和细胞系中检测出了SP细胞并验证这些SP细胞具有强干细胞活性。现有试验结果证实多种肺癌组织和肺癌肿瘤细胞系中也存在具有类干细胞特性的SP细胞,这些SP细胞的鉴别与分离对于肺癌肿瘤干细胞的研究有何意义?本文将整合现有研究资料就这一问题进行阶段性综述。
Side population (SP) cells are a small group of cells that can excrete the dye Hoechst 33342 to present a hypochromic Hoechst 33342 on a flow cytogram. Researchers have detected SP in various tumor tissues and cell lines Cells and verified that these SP cells have strong stem cell activity. The existing test results confirm that a variety of lung cancer and lung cancer cell lines also have the characteristics of stem cells SP cells, the identification and isolation of these SP cells for lung cancer stem cell research what is the significance of this article will integrate the existing research data The issue of a phased review.