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目的观察氨茶碱配合孟鲁司特干预慢性阻塞性肺疾病肺功能的效果。方法对2009年1月-2012年6月在我科就诊的慢性阻塞性肺疾病患者50例,采用按需吸入β2受体激动剂,口服氨茶碱0.1,1次/d,孟鲁司特钠10mg,1次/d。服药前1周及服药期间患者每日记录日、夜间喘息症状、β2受体激动剂的用量及可能出现的副作用。治疗前及治疗后3个月进行疗效评定,测定第1秒用力呼气容积(FEV1)及6min步行距离(6-MWT)测试。结果治疗前后FEV1(L)分别为1.75±0.64及2.97±0.21,P<0.05;6min步行距离(m)分别为278.6±18.2及468.1±15.9,P<0.05。治疗前后β2受体激动剂的用量(喷数/d)分别为1.90±0.97及0.45±0.27,P<0.05。未发现明显药物不良反应。结论氨茶碱配合孟鲁司特可有效改善慢性阻塞性肺疾病患者的肺功能,减轻呼吸困难程度,提高患者的活动耐力,生活质量得到改善。
Objective To observe the effect of aminophylline and montelukast intervention on pulmonary function in patients with chronic obstructive pulmonary disease. Methods Fifty patients with chronic obstructive pulmonary disease who were treated in our department from January 2009 to June 2012 were treated with on-demand inhaled β2-agonist, aminophylline 0.1,1 / d, montelukast Sodium 10mg, 1 time / d. Patients recorded daily, night wheezing symptoms, the amount of β 2 receptor agonist and possible side effects during the first week before and during the medication. The curative effect was evaluated before treatment and 3 months after treatment. The forced expiratory volume in one second (FEV1) and 6-minute walking distance (6-MWT) were measured. Results The FEV1 (L) before and after treatment were 1.75 ± 0.64 and 2.97 ± 0.21, P <0.05 respectively. The walking distance (m) at 6min was 278.6 ± 18.2 and 468.1 ± 15.9, respectively, P <0.05. The amount of β2 receptor agonist before and after treatment (spray number / d) were 1.90 ± 0.97 and 0.45 ± 0.27, respectively, P <0.05. No obvious adverse drug reaction was found. Conclusion The combination of aminophylline and montelukast can effectively improve lung function, alleviate the degree of dyspnea in patients with chronic obstructive pulmonary disease, improve patient endurance, and improve the quality of life.