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目的 :探讨心脏肌钙蛋白 I(c Tn I)对急性心肌梗死 (AMI)患者心功能预后的判断价值。方法 :AMI患者 34例(溶栓再通组 18例 ,未溶栓组 16例 ) ,每例患者采用序列采血测定血清 c Tn I,并检测 1月末左心室射血分数(L VEF)。结果 :AMI患者血清的 ∑c Tn I与 1月末 L VEF呈负相关 (P<0 .0 5 )。溶栓再通患者的 c Tn I峰值浓度与1月末 L VEF进行相关分析 ,有明显的负相关 (P<0 .0 5 ) ,未溶栓患者的 c Tn I峰值浓度与 1月末 L VEF无明显相关 (P>0 .0 5 ) ,溶栓再通患者 c Tn I峰值浓度明显高于未溶栓患者 (P<0 .0 1)。结论 :AMI患者的 ∑c Tn I和溶栓再通患者的峰值浓度均可作为判断左心功能的预后指标。
Objective: To investigate the value of cardiac troponin I (cTn I) in predicting cardiac function in patients with acute myocardial infarction (AMI). Methods: Thirty-four patients with AMI (18 in thrombolytic group and 16 in non-thrombolytic group) were enrolled in this study. Serum cTn I was measured by sequential blood sampling in each patient. Left ventricular ejection fraction (L VEF) at the end of January was measured. Results: There was a negative correlation between Σc Tn I in serum of patients with AMI and L VEF at the end of January (P <0.05). There was a significant negative correlation between cTn I peak concentration in patients with thrombolytic recanalization and L VEF in late January (P <0.05), no correlation between cTn I peak concentration in patients without thrombolysis and L VEF in late January (P> 0.05). The peak value of cTn I in patients receiving thrombolytic recanalization was significantly higher than that in patients without thrombolysis (P <0.01). CONCLUSIONS: Both Σc Tn I and the peak concentration of thrombolytic recanalization in patients with AMI can be used as predictors of left ventricular function.