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人类白细胞表面的Fc受体(FcγR)是免疫应答过程中将体液免疫系统同细胞效应功能结合起来的重要组分,根据其分子大小,对IgG的亲和力、细胞分布类型及体外功能FcγR至少可分为3大类。人类FcγRⅡ则是表达于单核细胞、血小板、嗜酸性粒细胞、B细胞及中性粒细胞表面的一种分子量为40000的糖蛋白,它可结合寡聚体形式的人IgG及小鼠IgGl和IgG2b,同时有证据表明单核细胞FcγR Ⅱ
The Fc receptor (FcγR) on the surface of human leukocytes is an important component in the immune response that combines the humoral immune system with cellular effector functions and is at least dividable according to its molecular size, affinity for IgG, cell distribution type, and in vitro functional FcγR For 3 categories. Human FcγRⅡ is a glycoprotein with a molecular weight of 40,000 expressed on the surface of monocytes, platelets, eosinophils, B cells and neutrophils. It binds to oligomers of human IgG and mouse IgG1 and IgG2b, while there is evidence that monocytes FcγR Ⅱ