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目的 :探讨 p2 7蛋白在喉癌组织中的表达及临床意义。方法 :以链亲合素 -生物素 L SAB免疫组化方法 ,测定 5 0例喉癌组织中 p2 7蛋白的表达 ,并以 15例声带息肉组织为对照。结果 :p2 7蛋白在喉鳞癌中的表达与声带息肉的表达差异有显著性意义 ;在喉癌临床分期中差异无显著性意义 ,在喉癌病理分级 G1 ～ G2 与 G3之间差异较明显 ,在有无颈淋巴结转移间差异无显著性意义 ,在喉癌术后 3年生存与死亡间差异有显著性意义。 p2 7蛋白表达阴性组和阳性组的生存率曲线 (Kaplan- m eier曲线 )差异有显著性意义。结论 :p2 7蛋白的表达与喉癌恶性程度有关 ,可作为判断喉癌的恶性程度和预后的重要指标。
Objective: To investigate the expression of p27 in laryngeal carcinoma and its clinical significance. Methods: The expression of p27 protein in 50 cases of laryngeal carcinoma was detected by streptavidin-biotin-L SAB immunohistochemistry, and 15 cases of vocal cord polyp were used as control. Results: The expression of p27 protein in laryngeal squamous cell carcinoma was significantly different from that of vocal cord polyp. There was no significant difference in the clinical stages between laryngeal squamous cell carcinoma and the difference between G1 ~ G2 and G3 There was no significant difference in the presence or absence of cervical lymph node metastasis. There was significant difference between the survival and death of laryngeal carcinoma 3 years after operation. There was significant difference in the survival rate curve (Kaplan-Meier curve) between the p27 protein negative group and the positive group. Conclusion: The expression of p27 protein is correlated with the degree of malignancy of laryngeal carcinoma, which may be used as an important index to judge the malignancy and prognosis of laryngeal carcinoma.