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目的:探讨影响宫腔内人工授精(IUI)临床妊娠率的各种相关因素。方法:回顾性分析本生殖中心实施IUI治疗的2011个周期。对女方年龄、不孕年限、授精时机及次数、方案、输卵管因素与妊娠结局的关系进行分析。结果:夫精人工授精(AIH)-IUI治疗1508个周期,临床妊娠率11.74%。供精人工授精(AID)-IUI治疗503个周期,临床妊娠率27.83%。二者比较有显著差异(P<0.05)。随着女性年龄增长,不孕年限延长,IUI的妊娠率逐渐降低。单次排卵前、单次排卵后和双次授精妊娠率无统计学差异;AIH诱导排卵的妊娠率高于自然周期。原发或继发不孕、单侧或双侧输卵管通畅间,妊娠率无统计学差异。结论:IUI中女方年龄、不孕年限、精子数量和用药方案是影响妊娠的重要因素。
Objective: To explore various factors that affect intrauterine insemination (IUI) clinical pregnancy rate. Methods: Retrospective analysis of the 2011 reproductive center implementation of IUI treatment cycle. The age of the woman, the duration of infertility, the timing and frequency of insemination, program, the relationship between tubal factors and pregnancy outcomes were analyzed. Results: Artificial insemination (AIH) -IUI treatment of 1508 cycles, the clinical pregnancy rate was 11.74%. For artificial insemination (AID) -IUI treatment of 503 cycles, the clinical pregnancy rate was 27.83%. There was a significant difference between the two (P <0.05). As women grow older, the duration of infertility is prolonged, and the pregnancy rate of IUI is gradually decreased. Single ovulation, single ovulation and double fertilization pregnancy rate was no significant difference; AIH induced ovulation pregnancy rate higher than the natural cycle. Primary or secondary infertility, unilateral or bilateral tubal patency, the pregnancy rate was no significant difference. Conclusion: Age, age of infertility, sperm count and medication regimen in IUI are important factors affecting pregnancy.