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目的探究急性心肌梗死患者经皮冠状动脉介入(PCI)术后应用前列地尔注射液治疗的效果。方法选取上海中医药大学附属岳阳中西结合医院心血管内科2015年5月—2016年2月收治的急性心肌梗死患者76例,按照随机数字表法分为对照组和研究组,各38例。患者均进行PCI术治疗,术后对照组采取常规治疗,研究组在对照组基础上联合前列地尔注射液治疗。观察对比两组患者治疗前后心功能指标〔射血分数(EF)、每搏输出量(SV)、舒张末期左房室瓣血流速度峰值(A)、舒张早期左房室瓣血流速度峰值(E)及E/A〕及治疗后B型钠尿肽(BNP)、心肌梗死面积、药物不良反应发生情况。结果治疗前两组患者EF、SV、A、E、E/A比较,差异无统计学意义(P>0.05)。治疗后,两组患者EF、SV、E、E/A均高于治疗前,A低于治疗前(P>0.05);且研究组EF、SV、E、E/A均高于对照组,A低于对照组,差异有统计学意义(P<0.05)。治疗后研究组BNP水平低于对照组,心肌梗死面积小于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论急性心肌梗死患者PCI术后应用前列地尔注射液效果良好,患者心功能明显改善,不良反应少,安全性高,具有较高的临床应用及推广价值。
Objective To investigate the effect of percutaneous coronary intervention (PCI) on the application of alprostadil injection in patients with acute myocardial infarction. Methods Sixty-six patients with acute myocardial infarction admitted from May 2015 to February 2016 in Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine were divided into control group and study group according to random number table. Patients were treated with PCI, after the control group to take conventional treatment, the study group in the control group based on the combination of alprostadil injection treatment. Before and after treatment, the comparison of the cardiac function indexes (ejection fraction (SV), stroke volume (SV), peak value of left atrioventricular valve velocity (A), peak value of left atrioventricular valve flow velocity (E) and E / A〕 and after treatment of B-type natriuretic peptide (BNP), myocardial infarction area, adverse drug reactions. Results There was no significant difference in EF, SV, A, E and E / A between the two groups before treatment (P> 0.05). After treatment, EF, SV, E, E / A in both groups were higher than before treatment, A was lower than before treatment (P> 0.05) A lower than the control group, the difference was statistically significant (P <0.05). After treatment, the level of BNP in the study group was lower than that in the control group, and the area of myocardial infarction was smaller than that in the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The application of alprostadil injection in patients with acute myocardial infarction is effective and the cardiac function of patients with acute myocardial infarction is improved obviously with less adverse reactions, high safety and high clinical application and promotion value.