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Objective Conflicting data have been generated from previous studies to determine which kind of relationship exists between HIV-1 specific CD8 T-cell responses and HIV-1 viral load or CD4 count over the course of infection.In this study,153 HIV-1 infected LTNPs were enrolled to investigate the role of HIV-1 specific CD8 T-cell responses in chronic HIV-1 infection among HIV-1 infected former blood donors.Methods The patients were stratified into three groups according to CD4 count:CD4≥500 cells/μL; 350 cells/μL≤CD4