一、概述消炎痛(Indocin)又名安汀番(Antifan)或吲哚新,是人工合成的吲哚生物,系阿斯匹林的同类药,均属前列腺素(PG)生物合成抑制剂。早于1935年,Von.Euler 发现 PG;1960年,Bergstr(?)n 阐明了 PG 的化学结构属于20碳的不饱和脂肪酸,以脂化形式存在于多数细胞膜的磷脂中。现知 PG 广泛存在于哺乳动物机体组织和体液中。几乎所有的组织均可产生,但血浆中的 PG 含量很少。血液流经肺、肝后 PG 的含量减少80—95%,因此不 First, an overview indomethacin (Indocin), also known as An Ting Fan (Antifan) or indole new, is a synthetic indole biology, aspirin similar drugs are prostaglandin (PG) biosynthesis inhibitors. As early as 1935, Von.Euler discovered PG; in 1960, Bergstr (?) N elucidated that the chemical structure of PG belongs to the 20-carbon unsaturated fatty acid and is present in lipid form in most cell membrane phospholipids. PG is now widely known in mammalian body tissues and body fluids. Almost all tissues can be produced, but plasma PG content is very small. Blood flow through the lung, liver PG content decreased by 80-95%, so no