他克莫司是一种强免疫抑制剂,是药物代谢酶 CYP3A 和药物转运蛋白 P-糖蛋白(P-gp)的底物,主要用于预防器官移植后的排斥反应。贯叶金丝桃为抗抑郁草药和CYP3A 与 P-gp 诱导剂,曾有1例肾移植患者发生他克莫司和贯叶金丝桃相互作用的报道。作者研究了贯叶金丝桃对健康受试者体 Tacrolimus is a potent immunosuppressive agent, a substrate for the drug metabolizing enzyme CYP3A and the drug transporter P-glycoprotein (P-gp), and is mainly used to prevent rejection after organ transplantation. Hypericum perforatum is an anti-depressant herb and inducer of CYP3A and P-gp. There has been a report of the interaction between tacrolimus and Hypericum perforatum in a patient with renal transplantation. The authors studied Hypericum perforatum on healthy subjects