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目的：探讨维生素Ｃ 在治疗新生儿缺氧缺血性脑病（ＨＩＥ） 中的最佳剂量。方法：早期（ 缺血再灌注６ ｈ 内） 静脉滴注大剂量维生素Ｃ（１ ｇ／ｋｇ·ｄ） 治疗ＨＩＥ４６ 例，并设对照组４６ 例对比观察。结果：治疗组显效３０ 例（６５－２ ％ ） 、中效９ 例（１９－６ ％ ） 、有效５ 例（１０－９ ％ ） 、总有效率９５－６ ％ ；对照组总有效率７３－９ ％ 。经统计学处理，两组差异有非常显著意义（ Ｐ＜０ ．０１） 。治疗组在意识恢复天数、肌张力恢复天数、反射恢复天数、惊厥控制天数等方面均比对照组明显缩短，且差异有非常显著意义（ Ｐ＜ ０ ．０１） 。结论：资料显示用此法治疗ＨＩＥ 效果显著，且未见不良反应。说明早期应用大剂量维生素Ｃ 治疗ＨＩＥ 是切实可行的。
Objective: To investigate the optimal dosage of vitamin C in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: 46 cases of HIE were treated by intravenous infusion of high dose vitamin C (1 g / kg · d) in the early stage (6 h after ischemia / reperfusion). Results: In the treatment group, 30 cases (65-2%) were markedly effective, 9 cases (19-6%) were effective, 5 (10-9%) were effective and the total effective rate was 95-6% 9%. Statistically, the difference between the two groups has a very significant (P <0 .01). The treatment group in conscious recovery days, days of muscle tone recovery, reflex recovery days, convulsions control days were significantly shorter than the control group, and the difference was significant (P <0 .01). Conclusion: The data show that the treatment of HIE with this effect was significant, and no adverse reactions. The early application of high-dose vitamin C treatment of HIE is feasible.