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目的了解开封市健康人群麻疹抗体水平,探寻免疫预防重点人群。方法采用酶联免疫吸附试验(ELISA)对开封市健康人群进行麻疹Ig G抗体水平血清学检测,并对结果进行统计学分析。结果 1 878名调查对象麻疹抗体阳性率为75.99%(1 427/1 878);抗体达保护性水平的比率为42.39%(796/1878),抗体几何平均浓度(GMC)为330.31IU/L。各年龄组人群麻疹抗体阳性率和抗体GMC差异均有统计学意义(χ2=648.59,P<0.001;F=127.61,P<0.01)。其中,1岁以下婴儿抗体阳性率和GMC分别为45.00%(333/740)、103.02IU/L;20~29岁青年为93.79%(166/177)、645.43IU/L;1~4岁儿童GMC最高,为982.01IU/L;而40岁以上人群抗体阳性率最高,为98.48%。城镇人群麻疹抗体GMC(364.51IU/L)高于农村人群(293.37IU/L)。患过麻疹的人群抗体阳性率和GMC分别为99.39%、998.96IU/L均高于未患人群(67.68%、222.73IU/L)。既往接种过含麻疹成分疫苗的人群抗体阳性率和GMC分别为89.23%、591.07IU/L均高于未种人群(66.58%、218.14IU/L)。结论开封市患过麻疹、接种含麻疫苗的人群抗体水平高,而<1岁婴儿和20~29岁人群抗体水平较低,为麻疹防控重点人群,需通过综合性免疫策略来进一步提高其抗体水平。
Objective To understand the level of measles antibody in healthy population in Kaifeng and explore the key population of immunoprophylaxis. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of measles IgG antibody in healthy subjects in Kaifeng City, and the results were statistically analyzed. Results The positive rate of measles antibody in 1 878 subjects was 75.99% (1 427/1 878). The ratio of antibody to protective level was 42.39% (796/1878). The antibody geometric mean concentration (GMC) was 330.31 IU / L. The positive rates of measles antibody and antibody GMC in all age groups were statistically significant (χ2 = 648.59, P <0.001; F = 127.61, P <0.01). Among them, the positive rate and GMC of infantile under 1 year old were 45.00% (333/740) and 103.02 IU / L, respectively, 93.79% (166/177) and 645.43 IU / L The highest GMC was 982.01 IU / L, while the highest positive rate was 98.48% in those over 40 years old. Measles antibody GMC (364.51 IU / L) of urban population was higher than that of rural population (293.37 IU / L). The positive rates of antibody and GMC in the patients with measles were 99.39% and 998.96 IU / L respectively, which were higher than those without (67.68%, 222.73IU / L). The positive rate of antibody and GMC of the population vaccinated with measles vaccine in the past were 89.23% and 591.07 IU / L, respectively, higher than that of the non-vaccinated population (66.58%, 218.14 IU / L). Conclusions Kaifeng had a high incidence of measles-infected patients and a high level of antibodies in those who received the vaccine containing measles vaccine. However, antibody levels were lower in children <1 year old and 20-29 years old, and were the key populations for measles prevention and control. Comprehensive immunization strategies were needed to further improve their antibody levels Antibody level.