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一、历史回顾Courvoisier等(1953)最早指出应用酚噻嗪类药物后可引起心电图的异常。她认为给动物反复投予大剂量氯丙嗪时,可导致房室及心室内传导时间延长、传导阻滞和心房纤维颤动并引起死亡。以后 Melville(1958)、Meville和Drapeau(1958)均报告了给动物用大量氯丙嗪(10mg/kg)作试验时,在心电图上可出现T波改变。因此都认为当给予大量氯丙嗪时可引起一过性的心脏结构损害。虽然以前,观察心电图变化的动物实验报告很多,但在人身上类似的报告却很少。
A historical review Courvoisier et al (1953) first pointed out that the application of phenothiazines can cause ECG abnormalities. In her opinion, repeated doses of chlorpromazine to animals can result in longer atrioventricular and ventricular conduction durations, conduction block and atrial fibrillation and cause death. Later, Melville (1958), Meville and Drapeau (1958) both reported that T wave changes could occur on the electrocardiogram when animals were tested with large amounts of chlorpromazine (10 mg / kg). It is therefore believed that when given a large number of chlorpromazine can cause transient cardiac structural damage. Although there have been a number of previous animal experiments that observed changes in ECG, similar reports were rarely reported in humans.