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氟虫腈英文通用名为fipronil,商品名Regent(锐劲特),是一种芳基吡唑型杂环类杀虫剂。氟虫腈具有长效性、高活性,对许多病菌均有抑制作用,并能促进植物生长,既可用于茎叶处理和土壤处理,又可用于种子处理,是代替高毒有机磷农药的首选品种之一。5-氨基-3-氰基-1-(2,6-二氯-4-三氟甲基苯基)吡唑,为芳基吡唑腈类化合物,分子式:C_(11)H_5Cl_2F_3N_4,CAS:120068-79-3。该化合物为合成氟虫腈的关键中间体。在5-氨基-3-氰基-1-(2,6-二氯-4-三氟甲基苯基)吡唑的合成文献中,都存在废酸排放过多,不易处理,使用试剂毒性较大,工业防护要求高等缺点。本课题组对该化合物的合成进行了研究,对筛选出的合成路线进行了改进。
Fipronil English common name fipronil, Regent (Regent), is an arylpyrazole type heterocyclic pesticides. Fipronil has a long-acting, high activity, inhibition of many germs, and can promote plant growth, both for stem and leaf treatment and soil treatment, but also for seed treatment, is the alternative to highly toxic organophosphate pesticides preferred One of the varieties. 5-Amino-3-cyano-1- (2,6-dichloro-4-trifluoromethylphenyl) pyrazole is an aryl pyrazole nitrile compound represented by the formula: C 11 H 5 Cl 2 F 3 N 4, CAS: 120068-79-3. This compound is a key intermediate in the synthesis of fipronil. In the synthetic literature of 5-amino-3-cyano-1- (2,6-dichloro-4-trifluoromethylphenyl) pyrazole there is excessive excretion of spent acid, which is not easy to handle, Larger, higher industrial protection disadvantages. The research group synthesized the compound was studied, the screening of the synthetic route has been improved.