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自身免疫性甲状腺疾患,即突眼性甲状腺肿和慢性(自身免疫性)甲状腺炎是青春期以后女性多发性疾病。患这种疾病的女性如果结婚,妊娠,有时不仅引起新生儿甲状腺机能异常,而且有时危及患儿的生命。近年,已明确了TSH受体的意义,并成为自身免疫性甲状腺疾病的病因,还明确了母亲的抗体活性和胎儿机能异常的关系。本文以新生儿突眼性甲状腺肿、一过性甲状腺机能低下症为主,对患有突眼性甲状腺肿、慢性甲状腺炎的母亲所生的新生儿做一叙述。一、胎儿甲状腺系统的发育和胎盘通透性问题人的甲状腺出现在胚胎10～12周左右,在组织上显示甲状腺形态的同时开始出现浓缩碘,并合成碘酪氨酸,这时还可检出促甲状腺激素(TSH)。从胚胎18周左右血中甲状腺素(T_4)、TSH上升,分娩后急速下降,生后第5日达到小儿正常值。血清三碘甲状腺氨
Autoimmune thyroid disorders, which are both sudden goitre and chronic (autoimmune) thyroiditis, are multiple female diseases after puberty. Women suffering from this disease if married, pregnant, and sometimes not only cause neonatal hypothyroidism, but also sometimes endanger the lives of children. In recent years, the significance of TSH receptors has been clarified and the etiology of autoimmune thyroid disease has been clarified. The relationship between maternal antibody activity and fetal dysfunction has also been clarified. In this paper, newborn sudden goiter, transient hypothyroidism based on the sudden onset of goiter, chronic thyroiditis born mothers make a narration. First, the development of the fetal thyroid system and placental permeability problems Human thyroid in the embryo 10 to 12 weeks or so, in the organization showed thyroid morphology at the same time began to appear concentrated iodine, and synthesis of iodine tyrosine, then still seized Thyroid stimulating hormone (TSH). Thyroxine (T_4), TSH increased from the embryo’s 18th week and dropped rapidly after delivery, reaching the normal value on the 5th day after birth. Serum triiodothyronine ammonia