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目的观察自体骨髓干细胞(bone marrow stem cells,BMSCs)动员联合神经营养因子及综合康复治疗持续植物状态(persistent vegetative state,PVS)患者的疗效及安全性。方法 60例PVS患者根据治疗方案分为对照组与观察组各30例,对照组给予神经营养因子及综合康复治疗,观察组在对照组治疗基础上行BMSCs动员治疗,比较2组治疗前、后PVS评分。结果治疗前观察组与对照组PVS评分分别为(0.92±0.67)和(0.91±0.75)分,差异无统计学意义(P<0.05);治疗后3,6个月、1a观察组PVS评分分别为(12.92±3.55),(13.58±3.53),(14.42±3.68)分,对照组分别为(10.45±4.58),(11.82±5.06),(12.27±5.06)分,2组比较差异均有统计学意义(P均<0.05);治疗后1a,观察组与对照组治愈率分别为80.0%,56.7%,差异有统计学意义(P<0.05);治疗过程中2组均未出现明显不良反应。结论 BMSCs动员联合神经营养因子及综合康复治疗PVS安全、疗效满意。
Objective To observe the efficacy and safety of autologous bone marrow stem cells (BMSCs) mobilization combined with neurotrophic factor and comprehensive rehabilitation of patients with persistent vegetative state (PVS). Methods 60 patients with PVS were divided into control group and observation group according to the treatment regimen, 30 cases in each group. The control group was given neurotrophic factor and comprehensive rehabilitation treatment. The observation group received mobilization treatment of BMSCs on the basis of the control group. score. Results Before treatment, the PVS scores of the observation group and the control group were (0.92 ± 0.67) and (0.91 ± 0.75) points respectively, with no significant difference (P <0.05). At 3 and 6 months after treatment, the PVS scores of the 1a observation group were respectively Were (12.92 ± 3.55), (13.58 ± 3.53) and (14.42 ± 3.68) respectively. The control group were (10.45 ± 4.58), (11.82 ± 5.06) and (12.27 ± 5.06) (P0.05) .After treatment, the cure rates of the observation group and the control group were 80.0% and 56.7% respectively (P <0.05), and no significant adverse reactions occurred in the two groups during the treatment . Conclusion BMSCs mobilization combined with neurotrophic factors and comprehensive rehabilitation of PVS safety, satisfactory results.