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目的对比戊酸雌二醇片雌二醇环丙孕酮片(克龄蒙)与结合雌激素片(倍美力)+醋酸甲羟孕酮序贯治疗卵巢早衰的临床疗效。方法 60例卵巢早衰患者,按照临床治疗方式的不同分为对照组(采用克龄蒙治疗)和观察组(采用倍美力+醋酸甲羟孕酮序贯治疗),每组30例。观察比较两组患者的临床治疗效果及不良反应情况。结果观察组患者的临床治疗总有效率86.67%,明显的高于对照组的63.33%(P<0.05)。观察组不良反应率23.33%,明显低于对照组的56.67%(P<0.05)。结论对卵巢早衰患者进行倍美力+醋酸甲羟孕酮序贯治疗,可以有效提高临床治疗效果,改善患者的生活质量。
Objective To compare the clinical efficacy of estradiol valerate valerate (Cyprimegesone tablets) combined with estrogen tablets (Betamert) + medroxyprogesterone acetate in the treatment of premature ovarian failure. Methods Sixty patients with premature ovarian failure were divided into control group (treated with jinglingmeng) and observation group (treated with bemelye + medroxyprogesterone acetate sequentially), 30 cases in each group according to the different clinical treatment methods. The clinical effects and adverse reactions of the two groups were observed and compared. Results The total effective rate of clinical treatment in observation group was 86.67%, significantly higher than that in control group (63.33%, P <0.05). Adverse reaction rate in observation group was 23.33%, which was significantly lower than 56.67% in control group (P <0.05). Conclusions The sequential treatment of Betamethazine and medroxyprogesterone acetate in patients with premature ovarian failure can effectively improve the clinical therapeutic effect and improve the quality of life of patients.